First, make sure apache and the script handling libraries are installed. On Ubuntu:
sudo apt-get install apache2 libapache2-mod-python libapache2-mod-fastcgi libapache2-mod-wsgi python-bobo
Then, make sure your script is executable by all
chmod a+x <scriptname.py>
Then, either in the .htaccess file, or in the global apache configuration, make sure the following lines are set
SetHandler wsgi-script
Options +ExecCGI
or
SetHandler cgi-script
Options +ExecCGI
SetEnv PYTHONPATH "pathyouwant"
Bobo can be installed in Ubuntu using the python-bobo package. To make bobo work with wsgi, you need to include the line:
application = bobo.Application(bobo_resources=__name__)